Marketed under the brand names Ozempic and Wegovy, semaglutide was the first FDA-approved injectable weight management drug and came out with a roar. These drugs are not entirely new, and oral semaglutide was approved by the FDA in September 2019 for use as an adjunctive therapy to improve blood sugar control in adults with type 2 diabetes. One notable side effect is dramatic weight loss, the rest is history.
“GLP-1 (glucagon-like peptide) receptor agonists, a class of drugs, have been on the market for the treatment of diabetes for over 15 years,” said MD emeritus professor at the Pennington Center for Biomedical Research in Baton Rouge, Louisiana. said Donna H. Ryan, “A similar compound, liraglutide, was approved for obesity in 2012, but semaglutide and lifestyle changes resulted in an average weight loss (or change in weight loss) of 15-17%. increase.”
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After a dramatic weight loss, Ozempic and his cousins took Hollywood by storm. Suspected but unconfirmed, Ozempic could be to blame for Kim Kardashian’s ability to match Marilyn Monroe’s dress for the 2022 Met Gala after losing over 15 pounds in three weeks Other celebrities have also received the memo saying they wanted to lose weight and so did those who could afford it. The drug is injectable and costs $1200 to $1500 per month .
Despite the fact that many celebrities have jumped on the bandwagon, the drug has benefits and could be a game-changer for people who are overweight or obese and struggling to lose weight. People with diabetes, diabetes, or prediabetes have the same metabolic problem, but the former isn’t called a ‘disease,'” said a trained and now practicing physician at the Albert Einstein College of Medicine in New York. explains Nina Karol, M.D., Ph.D., an internist who specializes in She is at Concierge Physicians in Westport, Connecticut. “They are just at different points in their progression trajectory and the body can no longer compensate and require medication (prediabetes and diabetes).”
Untreated overweight or obese people can develop prediabetes. And, of course, many pre-diabetics become diabetic. Semaglutide may interrupt this process, prevent diabetes from progressing or developing, and reduce the risk of hypertension, nerve damage, cardiovascular disease, and stroke.
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Dr. Ryan says you’re more likely to put the weight back on when you stop taking the drug. If you stop taking semaglutide, your weight will return. Short-term use of semaglutide has not been demonstrated in clinical trials, so semaglutide could be a long-term commitment.
And it’s not without side effects. As with any drug, side effects are real. Semaglutide can cause nausea, vomiting, diarrhea, kidney problems, and thyroid tumors in susceptible people. “The company wasn’t ready for the demand,” says Dr. Ryan. As a result, some of his type 2 diabetic patients taking Ozempic have a hard time getting diabetes. “As a temporary measure, they can be switched to another of her GLP-1 receptor agonists, dulaglutide, liraglutide, or exenatide.”
This drug class is undoubtedly well-established and, when used as intended, has the potential to reduce and prevent severe morbidity and mortality in a very large number of people suffering from overweight, obesity and pre-diabetes. Yes. “Physicians are allowed to prescribe off-label,” says Dr. Karol.
The views expressed in this article are those of the author and do not necessarily reflect the editorial policy of Fair Observer.
