Study shows postbiotic Urolithin A improves muscle strength and exercise performance in middle aged adults

Age-related muscle weakness can begin as early as 40 years, and there is currently no effective intervention to counteract it other than exercise.New milestone research announced today Cell Reports Medicine Daily intake of Amagentis’ unique urolithin A, Mitopure, has been shown to significantly improve muscle strength by 12% after 4 months. These findings further examine the benefits of Mitopure for muscle and mitochondrial health and show that it is safe and well tolerated. Mitopure works by supporting the ability of cells to regenerate mitochondria, the power plant of the cell, during aging. Muscles have a high demand for energy, and muscle cells have a large number of mitochondria.

Previous studies have shown that Mitopure improves muscle endurance, reduces inflammation, and makes mitochondrial function healthier in the 65-90 year old. This new double-blind, placebo-controlled trial was conducted in London, Ontario, Canada, in London, Canada, for middle-aged adults (n = 88) aged 40 to 64 years, with IRB approval from the Canadian Ministry of Health. .. Participants were randomized to receive either 500 mg, 1,000 mg of mitopre or placebo daily for 4 months. Skeletal muscle biopsy and plasma strength, exercise performance tests, and biomarkers of healthy mitochondrial function and inflammation were evaluated at baseline, 2 and 4 months.

• Two measurements of skeletal muscle strength were improved in the supplement group compared to the placebo group. Hamstring skeletal muscle strength was significantly increased in both the 500 mg (+ 12%) and 1,000 mg (+ 9.8%) groups. Knee flexion muscle strength was also significantly improved at both 500 mg (+ 10.6%) and 1,000 mg (+ 10.5%).
• Clinically meaningful improvement in aerobic endurance (+ 10% at peak oxygen consumption) [VO2]), Physical performance (+ 33 meters in a 6-minute walk test), and output (+ 5%) were observed in the 1,000 mg group, although not statistically significant.
• Blood tests and biopsies showed a significant improvement in biomarkers of healthy mitochondrial function and a reduction in inflammation

“These results are exciting because they are the first in a human demonstration that urolithin A can repair mitochondria via mitophagy and lead to significant physiological benefits. In addition, participants’ exercise routines. There was an improvement in intensity and athletic performance without making any changes to the EPFL professor Johan Auwerx, MD, Ph.D., co-author.

This is an important finding in the study of longevity and muscle health. Aging is associated with decreased mitochondrial function and can lead to decreased athletic performance, muscular endurance, and muscular strength. Urolithin A is the first and only compound clinically shown to improve muscle function by regenerating mitochondria through a powerful biological quality control mechanism called mitophagy. By activating this important biological pathway, Mitopure promotes healthy aging and improves muscle health and performance.

“This study further examines the role of mitochondrial health as an important pillar of vitality and shows that Mitopre is the first nutrient in its class to have a meaningful impact on muscle health. We are proud to offer this unique Urolithin A within Health. Scientific Products. ” Chris Linsch, CEO and co-founder of Amagentis, said. “We continue to develop clinically validated products that optimize cell health with the mission of keeping millions of people healthy longer.”

“Mitochondrial decline is an important feature of poor aging and metabolic health. This study is an important milestone and shows that urolithin A has the potential to become a game changer in our field. I will. ” Dr. Eric Birdin, President and Chief Executive Officer of the Back Institute for Aging Institute, who has just joined the Scientific Advisory Group of Amagentis.