According to a recently published study, a conjugated linoleic acid dietary supplement resulted in weight loss in a mouse model of Prader-Willi Syndrome (PWS).
The results were detailed in the journal NutrientsIn the article “Diet-conjugated linoleic acid reduces body weight and fat in Snord116m + / p- and Snord116m- / p-mouse models of Prader-Willi syndrome.. “
Most cases of PWS are caused by a deletion of genetic material in a specific part of chromosome 15. Mutations that cause PWS SNORD116 get together.Evidence shows that this cluster regulates the activity of another gene called NHLH2..
Missing mouse NHLH2Called the N2KO mouse, was developed in the late 1990s and shows some of the same signs and symptoms of Prader-Willi syndrome. Recent studies have shown that adding conjugated linoleic acid supplements to the diet of N2KO mice results in weight loss.
Conjugated linoleic acid (CLA) is a type of fat molecule commonly found in certain foods such as beef and dairy products. It is “generally considered safe” by the US Food and Drug Administration, and supplements are available over-the-counter in the United States.
In this study, a team of researchers in the United States set out to test whether CLA supplements induce weight loss in PWS mouse models similar to those found in N2KO mice.
The researchers used mice lacking the SNORD116 cluster in their paternal copy. Although these mice do not develop overt weight loss, the genetic variation they carry “is genetically most similar to the minimal deletion in humans that results in PWS,” the team writes.
As a result of feeding all mice with a high-fat diet, it was found that the mice fed with CLA lost weight. CLA induced weight loss in PWS and control mice.
Further analysis showed minimal differences in metabolic activity, exercise performance, or food intake between mice given and not given CLA. Dietary supplements were also not harmful to muscle function.
“These data suggest that CLA treatment has effects other than food intake and exercise on body weight,” the researchers wrote, stating that potential mechanisms need to be further investigated. rice field.
Evidence of steatosis, a condition characterized by an abnormal amount of fat in the liver, was found by CLA supplementation in about half of all wild-type (control) and PWS mice. Researchers also called for further research into the reasons for these differences.
