According to a team of researchers at the main university, muscular dystrophy is a debilitating illness that causes skeletal muscle weakness and collapse that gradually worsens over time. A study published in the journal ELife understands that certain activities may help strengthen muscles affected by muscular dystrophy by observing zebrafish stimulating and exercising. did.Also read-four important tips for building and strengthening immunity, nutritionists suggest
Zebrafish are an effective test model for muscular dystrophy because of the similar molecules in human muscles to zebrafish. Zebrafish can also be bred with mutations that closely model Duchenne muscular dystrophy. This is a severe form of muscular dystrophy that affects young boys. Read again-Why do you find it difficult to exercise again after a break?About the “vital protein” that is stopping you here
However, because zebrafish cannot lift weights, UMaine researchers used a process called neuromuscular electrical stimulation (NMES) that stimulates specific nerves to induce muscle contraction. Researchers have designed four NMES regimens and named them after four common weightlifting routines (power, strength, hypertrophy, endurance). Read also-Viral video: Faridabad man who saw him exercising hanging from the balcony on the 12th floor scares the internet | Clock
Next, the zebrafish were placed in an underwater 3D-printed “gym” consisting of tunnels and electrodes, and researchers analyzed skeletal muscles to see how they changed.
In this study, each of the NMES weightlifting “routines” had different effects on zebrafish neuromuscular junction morphology, swimming, and survival, while improving all three as long as they were associated with specific neuromuscular stimulation. It turns out that there is only one. Antioxidants, heme oxygenase, and a receptor called integrin alpha 7.
“ENMES is defined by high frequency, low voltage pulses. This is similar to high frequency, low weight training done in. A long-standing consensus in the field of muscular dystrophy is to minimize strength training. However, our data show that a certain level of NMES-induced activity is actually beneficial to overall muscle health, as it reduces the risk of muscle damage and thus maintains strength and mass. It suggests that there is, “said Elisabeth Kilroy, lead author of a doctoral degree study at UMaine. Kilroy is currently the Director of the Neuromuscular Observational Study (MOVR) of the Muscular Dystrophy Association.
This study suggests that the right type of strength training may be beneficial to human patients with muscular dystrophy. Although NMES may improve mobility and strength in patients with muscular dystrophy, little is known about applying this technique in this way.
“The most exciting aspect is the establishment of a model of neuromuscular plasticity in healthy and diseased muscles, which will enable us to elucidate the mechanisms underlying potential future therapies.” Said Professor Clarissa Henry. Dean of the Graduate School of Bioscience and Biomedical Engineering, Chief Director of the Henry Institute.
(With ANI input)
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